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cftr inh172  (MedChemExpress)


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    MedChemExpress cftr inh172
    Cftr Inh172, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cftr inh172/product/MedChemExpress
    Average 94 stars, based on 25 article reviews
    cftr inh172 - by Bioz Stars, 2026-03
    94/100 stars

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    A . NF-κB activity in H441 cells transfected with either empty vector or wt-CFTR (400 ng), each treated with 10 µM CFTR <t>inh172</t> for 4 hours, n = 3 *p<0.05 (compared to empty vector control), # p<0.05 (compared to CFTR control). B . NF-κB activity in 16HBE14o − cells treated with 10 µM CFTR inh172 and/or 10 µM forskolin and 100 µM IBMX for 4 h, n = 7, *p<0.05. C . IL-8 levels in supernatants from 16HBE14o − cells measured by ELISA, n = 8, p not significant. D IL-8 levels in supernatants from primary human nasal epithelial cells treated with 10 µM CFTR inh172 for 4 hours, n = 4, *p<0.05.
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    A . NF-κB activity in H441 cells transfected with either empty vector or wt-CFTR (400 ng), each treated with 10 µM CFTR <t>inh172</t> for 4 hours, n = 3 *p<0.05 (compared to empty vector control), # p<0.05 (compared to CFTR control). B . NF-κB activity in 16HBE14o − cells treated with 10 µM CFTR inh172 and/or 10 µM forskolin and 100 µM IBMX for 4 h, n = 7, *p<0.05. C . IL-8 levels in supernatants from 16HBE14o − cells measured by ELISA, n = 8, p not significant. D IL-8 levels in supernatants from primary human nasal epithelial cells treated with 10 µM CFTR inh172 for 4 hours, n = 4, *p<0.05.
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    A . NF-κB activity in H441 cells transfected with either empty vector or wt-CFTR (400 ng), each treated with 10 µM CFTR inh172 for 4 hours, n = 3 *p<0.05 (compared to empty vector control), # p<0.05 (compared to CFTR control). B . NF-κB activity in 16HBE14o − cells treated with 10 µM CFTR inh172 and/or 10 µM forskolin and 100 µM IBMX for 4 h, n = 7, *p<0.05. C . IL-8 levels in supernatants from 16HBE14o − cells measured by ELISA, n = 8, p not significant. D IL-8 levels in supernatants from primary human nasal epithelial cells treated with 10 µM CFTR inh172 for 4 hours, n = 4, *p<0.05.

    Journal: PLoS ONE

    Article Title: Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling

    doi: 10.1371/journal.pone.0011598

    Figure Lengend Snippet: A . NF-κB activity in H441 cells transfected with either empty vector or wt-CFTR (400 ng), each treated with 10 µM CFTR inh172 for 4 hours, n = 3 *p<0.05 (compared to empty vector control), # p<0.05 (compared to CFTR control). B . NF-κB activity in 16HBE14o − cells treated with 10 µM CFTR inh172 and/or 10 µM forskolin and 100 µM IBMX for 4 h, n = 7, *p<0.05. C . IL-8 levels in supernatants from 16HBE14o − cells measured by ELISA, n = 8, p not significant. D IL-8 levels in supernatants from primary human nasal epithelial cells treated with 10 µM CFTR inh172 for 4 hours, n = 4, *p<0.05.

    Article Snippet: 24 h post transfection, cells were treated with combinations of 10 ng/ml TNFα, to stimulate NF-κB activity, 10 µM CFTR inh172 (Merck, Nottingham, U.K.), to inhibit CFTR and 10 µM Forskolin and 10 µM IBMX to stimulate PKA by elevating cAMP.

    Techniques: Activity Assay, Transfection, Plasmid Preparation, Enzyme-linked Immunosorbent Assay